HIGH-CONTENT SCREENING (HCS)
The ability to identify how novel compounds, peptides or RNAis alter the phenotype of a cell is hugely important in modern drug discovery. High throughput, good resolution and high sensitivity are three critical prerequisites for an efficient HCS system, but are often hard to combine. Although several premium systems nowadays include confocal optics, they lack sensitive cameras. This means in practice that fluorescence imaging is slow with high noise levels and increased photobleaching, especially when taking time-laps images.
Model Theta doesn't compromise when it comes to throughput, sensitivity and resolution, and it's simple to perform the measurements. A plate is imaged at diffraction-limited resolution in 2D in 14.5 minutes with virtually no photobleaching. In addition 3D imaging can easily be performed as well as more complex imaging processing such as spatio-temporal correlation spectroscopy.
We also believe that combining HCS with in situ sequencing or digital ELISA in the way that Model Theta does is a major advance for the drug discovery industry.